In order to find policy and practical implications for promoting the happiness of the disabled, this study looked at the relationship between positive interpersonal relationships and happiness of wage workers with disabilities by examining the mediating effects of self-efficacy and job satisfaction in it. To this end, based on Alderfer's ERG theory and previous research on happiness, the relationship between the key variables and other variables was constructed as a research model and analyzed through a structural equation model. For the analysis data, the study used data from the 7th year of the 2nd wave survey of the disabled employment panel survey provided in 2022 by the Employment Development Institute for the Disabled under the Korea Employment Agency for the Disabled in 2022. The analysis revealed that the level of happiness was low among wage workers who are older in ages, with low level of education, and with physical and external disabilities. In addition, self-efficacy and job satisfaction showed a complete mediating effect in the relationship between positive interpersonal relationships and happiness. These results suggest that there is a need for an institutional mechanism that can remove the discriminatory factors prevalent in Korean society, and that, in order to help form the formation of positive interpersonal relationships for the disabled, practical interventions in various dimensions are needed.